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2008
Konstantakaki, M, Tzartos, S.J., Poulas, K. and Eliopoulos, E. (2008). Μodel of the extracellular domain of the human α7 nAChR based on the crystal structure of the mouse α1 nAChR extracellular domain. J. Mol. Graph Modelling. 26: 1333-7.
Bitzopoulou, K., ,Kostelidou, K., Poulas, K and Tzartos, S.J. (2008) Expression and characterization of mutant forms of the extracellular domain of the human AChR gamma-subunit with improved solubility and enhanced antigenicity. Biochem. Biophys. Acta. 1784: 1226-33
Zisimopoulou, P., Lagoumintzis, G., Poulas, K. and Tzartos, S.J. (2008). Antigen-specific apheresis of human anti-acetylcholine receptor autoantibodies from myasthenia gravis patients’ sera using Escherichia coli-expressed receptor domains. J. Neuroimmmunol. 200: 133-141.
Keefe, D., Hess, D., Dosco, J., Tzartos, S., Powell, J., Lamsa. J., and Josiah, S. (2008) A rapid, fluorescence based assay for detecting antigenic modulation of the acetylcholine receptor on human cell lines. Cytometry B Clin Cytom. Epub ahead of print.
Yi, H.J., Chae, C.S., So, J.S., Tzartos, S.J. Souroujon MC, Fuchs, S., Im, SH (2008) Suppression of experimental myasthenia gravis by a B-cell epitope-free recombinant acetylcholine receptor. Mol. Immunol. 461:192-201.
Zouridakis M, Zisimopoulou P, Eliopoulos E, Poulas K, and Tzartos SJ (2008) Design and expression of human α7 nicotinic acetylcholine receptor extracellular domain mutants with enhanced solubility and ligand-binding properties. Bioch. Bioph. Acta. Epub ahead of print.
2007
Konstantakaki, M., Tzartos, S.J., Poulas, K., and Eliopoulos, E. (2007) Molecular modeling of the complex between Torpedo acetylcholine receptor and anti-MIR Fab198. Biochem. Biophys. Res. Commun. 356:569-75.
Sideris, S., Lagoumintzis, G., Kordas, G., Kostelidou, K., Sotiriadis, A, Poulas, K. and Tzartos, S.J. (2007) Isolation and functional characterization of anti-acetylcholine receptor subunit-specific autoantibodies from myasthenic patients: receptor loss in cell culture. J. Neuroimmunol. 189:111-7.
Zouridakis, M., Kostelidou, K., Sotiriadis, A., Stergiou, Ch. Eliopoulos, E., Poulas, K., and Tzartos, S. (2007) Circular Dichroism Studies of Recombinant Extracellular Domains of Human Muscle and Neuronal Nicotinic Acetylcholine Receptors Provide an Insight into their structure. Intl. J. Biol. Macromol. 41:423-9.
Kostelidou, K., Trakas,N. and Tzartos, S.J. (2007) Extracellular domains of the β, γ and ε subunits of the human acetylcholine receptor as immunoadsorbents for myasthenic autoantibodies: a combination of immunoadsorbents results in increased efficiency. J. Neuroimmmunol. 190:44-52.
2006
Kostelidou, K., Trakas,N., Zouridakis, M., Bitzopoulou, K., Sotiriadis,A., Gavra, H., and Tzartos, S.J. (2006). Expression and characterization of soluble forms of the extracellular domains of the β, γ and ε subunits of the human muscle acetylcholine receptor. FEBS J. 273: 3557-3568
Fostieri, E., Tzartos, S.J., Berrih-Aknin, S., Beeson, D. and Mamalaki A. (2005) Isolation of potent human Fab fragments against a novel highly immunogenic region on human muscle acetylcholine receptor, which protect the receptor from myasthenic autoantibodies. Eur. J. Immunol. 35:632-643.
2000- 2005
Protopapadakis, E., Kokla, A., Tzartos, S.J. and Mamalaki, A (2005) Isolation and characterization of human anti-acetylcholine receptor monoclonal antibodies from transgenic mice expressing human immunoglobulin loci. Eur. J. Immunol. 35:1960-68.
Guyon, S., Christadoss, P., Lepanse, R, Guyon, T, DePoea Baets, M., Wakkach, A., Bidault, J., Tzartos, S., and Berrih-Aknin, S. (2005) Effects of cytokines on AChR expression. Implications for myasthenia gravis. J. Immunol. 174: 5941-49.
Psaridi-Linardaki, L., Mamalaki, A., Trakas, N. and Tzartos, S.J. (2005) Specific immunoadsorption of the autoantibodies from myasthenic patients using the extracellular domain of the human muscle acetylcholine receptor α-subunit. Development of an antigen-specific therapeutic strategy. J. Neuroimmunol. 159:183-91.
Avramopoulou, V., Mamalaki, A., Tzartos, S.J. (2004) Soluble, oligomeric and ligand-binding extracellular domain of human alpha7 acetylcholine receptor expressed in yeast. Replacement of the hydrophobic cys-loop by the hydrophilic loop of ACh-binding protein enhances protein solubility. J. Biol. Chem. 279: 38287-93.
Marinou, M. and Tzartos, S.J. (2003). Identification of regions involved in the binding of α-Bungarotoxin to the human α7 neuronal nicotinic acetylcholine receptor using synthetic peptides. Biochem. J. 372, 543-554.
Phan-Chan-Du, A., Hemmerlin, C., Krikorian, D., Sakarellos-Daitsiotis, M., Tsikaris, V., Sakarellos, C., Marinou. M.,Thureau, A., Cung, M.T. and Tzartos, S.J. (2003). Solution conformation of the antibody-bound tyrosine phosphorylation site of the nicotinic acetylcholine -subunit in its phosphorylated and nonphosphorylated states.receptor Biochemistry, 42:7371-7380.
Campos, E.C., Schiavi, C., Bolognesi, A., Bellusci, C., Lubelli, C., Duca, A., Polito, L., Vismara, S., Poulas, K., Tzartos, S.I., and Stirpe, F. (2002). Selective lesions of rabbit extraocular muscles injected with the anti-AChR immunotoxin saporin-mAb 73. Curr. Eye Res. 24: 58-65.
Psaridi-Linardaki, L.,Mamalaki, A., Remoundos, M. and Tzartos, S.J. (2002). Expression of soluble ligand- and antibody-binding extracellular subunit in yeast Pichiadomain of human muscle acetylcholine receptor α- pastoris. Role of glycosylation in α-bungarotoxin binding. J. Biol. Chem. 277: 26980-6.
Μetaxas, A., Tzartos, S., Liakopoulou-Kyriakide, M. (2002). The production of anti-hexapeptide antibodies which recognize the S7, L6 and L13 ribosomal proteins of Escherichia coli. J Pept Sci. 8:118-24.
Tataridis, D., Kolocouris, A., Fytas, G., Kolocouris, N., Foscolos, G.B., Poulas, K. and Tzartos, S.J. (2002).Mounting the nicotinic pharmacophoric structural elements in an homoadamantane scaffold: synthesis, molecular modeling and binding affinities to α7 nicotinic acetylcholine receptors. IL Farmaco. 57:979-984.
Poulas, K. and Tzartos, S.J (2001). The gender gap in autoimmune disease. Letter to Lancet, 357, 234.
Poulas, K., Eliopoulos, E., Vatzaki, E., Navaza, J., Kontou, M., Oikonomakos, N., Acharya, K.R., and Tzartos, S. J. (2001). Crystal structure of Fab198, an efficient protector of acetylcholine receptor against myasthenogenic antibodies. Eur. J. Biochem. 268: 3685-3693.
Poulas, K., Tsibri, E., Papanastasiou, D., Tsouloufis, T., Marinou, M., Tsantili, P., Papapetropoulos, T., and Tzartos, S.J. (2001). Epidemiology of seropositive myasthenia gravis in Greece. J. Neurol. Neurosur. Psych. 71:352-6.
Theodorou, V.,Tsikaris, V., Sakarellos-Daitsiotis, M, Avramopoulou, V., Kostelidou, K., Tzartos, S.J. and Sakarellos, C. (2001). Design, synthesis and conformational study of biologically active photolabeled analogues of the Main Immunogenic Region of the acetylcholine receptor. Biopolymers. 56: 37-46.
Trakas, N. and Tzartos, S.J. (2001) Conjugation of acetylcholine receptor-protecting Fab fragments with polyethylene glycol results in a prolonged half-life in the circulation and reduced immunogenicity. J. Neuroimmunol. 120:42-49.
Skok, M., Lykhmus, E., Bobrovnik, S., Tzartos, S.I., Tsouloufis, T., Vanderesse, R. , Coutrot, F., Cung, M.T., Marraud, M., Krikorian, D., and Sakarellos-Daitsiotis, M. (2001). Structure of epitopes recognized by the antibodies to alpha (181-192) peptides of neuronal nicotinic acetylcholine receptors: extrapolation to the structure of acetylcholine-binding domain. J. Neuroimmunol. 121: 59-66.
Kleinjung, J., Petit, M-C., Orlewski, P., Mamalaki, A., Tzartos, S.J., Tsikaris, V., Sakarellos-Daitsiotis, M., Sakarellos, C., Marraud, M. and Cung. M.-T. (2000). The 3D structure of the complex between an Fv antibody fragment and an analogue of the main immunogenic region of the acetylcholine receptor: A combined 2D-NMR, homology and molecular modeling approach. Biopolymers. 53: 113-128
Sevin-Landais, A., Rigler, P., Tzartos, S., Hucho, F., Hovius, R. and Vogel, H. (2000). Immobilisation of the nicotinic acetylcholine receptor in tethered lipid membranes. Biophys. Chem. 85:141-52.
Poulas, K., Tsouloufis, Th., and Tzartos S.J. (2000) Treatment of passively transferred experimental autoimmune myasthenia gravis using papain. Clin. Expl. Immunol. 120:363-368.
Tsouloufis, T., Mamalaki, A., Remoundos, M. and Tzartos, S.J. (2000). Reconstitution of conformationally-dependent epitopes on the N-terminal extracellular domain of the human muscle acetylcholine receptor α-subunit expressed in E. coli. Implications for Myasthenia Gravis therapeutic approaches. Int. Immunol. 12: 1255-65.
Papanastasiou, D., Poulas, K., Kokla, A and Tzartos, S. J. (2000). Prevention of passively transferred experimental autoimmune myasthenia gravis by Fab fragments of monoclonal antibodies directed against the main immunogenic region of the acetylcholine receptor. J. Neuroimmunol. 104:124-132.
Kontou, M., Leonidas, D., Vatzaki, E.H., Tsantili, P., Mamalaki, A., Oikonomakos, N.G., Acharya, K.R, and Tzartos, S. J. (2000).The crystal structure of the Fab fragment of a rat monoclonal antibody against the main immunogenic region of the human muscle acetylcholine receptor. Eur. J. Biochem. 267:2389-2397
Michalet, S., Teixeira, F., Gilquin, B., Mourier, G., Servent, S., Drevet, P., Binder, P., Tzartos, S., Ménez, A., and Kessler, P. (2000). Relative spatial position of a snake neurotoxin and the reduced disulfide bond αCys192-Cys193) at the αγ interface of the nicotinic acetylcholine receptor. J. Biol. Chem. 275: 25608-25615.
Sieb, J.P., Kraner, S., Schrank, B., Reitter, B., Goebel, H.H., Tzartos, S. J. and Steinlein, O.K. (2000). Severe congenital myasthenic syndrome due to homozygosity of the 1293insG ε-AChR subunit mutation. Ann. Neurol. 48:379-83
Fostieri, E., Beeson, D. and Tzartos, S.J. (2000). The conformation of the main immunogenic region on the α-subunit of muscle acetylcholine receptor is affected by neighboring receptor subunits. FEBS Lett. 481: 127-130.
Poulas, K., Tsibri, E., Papanastasiou, D., Tsouloufis, T., Marinou, M., Tsantili, P., Papapetropoulos, T., and Tzartos, S.J. (2000). Equal male and female incidence of myasthenia gravis. Neurology, 54, 1202-1203.
1990-1999
Nenninger, R., Schultz, A., Helmreich, M., Wilisch, A., Vandekerckhove, B., Hunig, T., Schalke, B., Tzartos, S.J., Kahlbacher, H., Muller-Hermelink, H. and Marx, A. (1998). Abnormal thymocyte development - Generation of autoaggressive T-cells in mixed and cortical thymomas. Lab. Invest. 78:743-753.
Tsantili, P., Tzartos, S.J. and Mamalaki, A. (1999) High affinity scFv antibody fragments protecting the human nicotinic acetylcholine receptor. J. Neuroimmunol. 94: 15-27.
Papanastasiou, D., Mamalaki, A., Eliopoulos, E., Poulas, K., Liolitsas Ch. and Tzartos, S.J. (1999). Construction and characterization of a humanized single chain Fv antibody fragment against the main immunogenic region of the acetylcholine receptor. J. Neuroimmunol. 94: 182-195.
Tzartos, S.J. and Remoundos, M. (1999). Detection of antibodies directed against the cytoplasmic region of the human acetylcholine receptor in sera from myasthenia gravis patients. Clin. Expl. Immunol. 116: 146-152.
Skok, M.V., Voitenko, L. P., Voitenko, S. V., Lykhmus, E. Yu., Kalashnik, E. N., Litvin, T. I., Tzartos S. J. and Skok, V. I. (1999). Alpha subunit composition of nicotinic acetylcholine receptors in the rat autonomic ganglia neurons as determined with subunit-specific anti-α(181-192) peptide antibodies. Neuroscience. .93: 1436-1447.
Wilisch, A., Gutsche, S., Hoffacker, V., Schultz, A., Tzartos, S., Nix, W., Schalke, B., Schneider, C., Muller- Hermelink, H. K. and Marx A. (1999). Association of acetylcholine receptor α-subunit expression in mixed thymoma with myasthenia gravis. Neurology. 52: 1460-1466.
Schultz, A., Hoffacker, V.,Wilisch, A., Nix, W., Schalke, B., Nix, W., Tzartos, S., Muller-Hermelink, H. K. and Marx A. (1999). Neurofilament is an autoantigenic determinant in myasthenia gravis. Ann. Neurology. 46: 167-75.
Martin-Ruiz, C.M., Court, J.A., Molnar, Ε., Lee, Μ., Gotti, C., Mamalaki, A., Tsouloufis, T., Tzartos, S., Ballard, C., Perry, R.H. and Perry, E.K. (1999) Alpha 4 but not alpha 3 and 7 nicotinic acetylcholine receptor subunits are lost from the temporal cortex in Alzheimer's disease. J. Neurochem. 73: 1635-1640.
Jacobson, L., Beeson, D., Tzartos, S. and Vincent, A. (1999). Monoclonal antibodies raised against human acetylcholine receptor bind to all five subunits of the fetal isoform. J. Neuroimmunol. 98: 112-120.
Wakkach, A., Poea, S., Chastre, E., Gespach, C., Lecerf, F., De la Porte, S., Tzartos, S., Coulombe, A., and Berrih-Aknin, S. (1999). Establishment of a thymic myoid cell line: phenotypic and functional characteristics. Am. J. Pathol. 155:1229-1240
Sieb, J.P., Dorfler, P., Tzartos, S., Wewer, U., Ruegg, M.,Meyer, D., Baumann, I., Lindemuth, R., Jakschik, J. and Ries, F. (1998). Congenital myasthenic syndromes in two kinships with endplate acetylcholine receptor and utrophin deficiency. Neurology, 50: 54-61.
De la Porte, S., Chaubourt, E., Fabre, F., Poulas, K., Chapron, J., Eymard, B., Tzartos, S.J., and Koenig, J. (1998). Accumulation of acetylcholine receptors is a necessary condition for normal accumulation of acetylcholinesterase during in vivo neuromuscular synaptogenesis. Eur. J. Neurosci., 10: 1631-1643.
Barchan, D., Asher, O., Tzartos, S.J., Fuchs, S. and Souroujon, M. (1998). Modulation of the anti-acetylcholine receptor and experimental autoimmune myasthenia gravis by recombinant fragments of the acetylcholine receptor. Eur. J. Immunol. 28:616-624.
Gattenloehner, S., Vincent, A., Leuschner, I., Tzartos, S., Kirchner, T., Muller-Hermelink, H.-K., Marx, A. (1998) Investigation of the acetylcholine receptor in rhabdomyosarcomas as compared with other childhood tumors. Am. J. Pathol. 152: 437-444.
Guyon, T., Wakkach, A., Klingel-Schmitt, I., Levasseur, P., Beeson, D., Asher, O., Tzartos, S.J. and Berrih-Aknin, S. (1998). Regulation of acetylcholine receptor gene expression in human myasthenia gravis muscles. Evidence for a compensatory mechanism triggered by receptor loss. J. Clin. Invest. 102: 249-263.
Orlewski, P., Marraud, M., Cung, M.T, Tsikaris, V., Sakarellos-Daitsiotis, M., Sakarellos, K., Vatzaki, E. and Tzartos, S.J. (1996). Compared structures of the free AChR MIR decapeptide and the antibody-bound [A76]MIR analogue. A molecular dynamics simulation from 2D-NMR data. Biopolymers (Peptide Science). 40: 419-432.
Gotti, C., Balestra, B., Mantegazza, R., Tzartos, S., Moretti, M. & Clementi, F. (1997) Detection of antibody subpopulations in myasthenia gravis using a non radioactive new enzyme immunoassay. Muscle & Nerve, 20: 800-808.
Loutrari, H., Kokla, A., N. Trakas and Tzartos, S.J. (1997). Expression of human-Torpedo hybrid acetylcholine receptors for analyzing the antigenic specificities in myasthenic antisera. Clin. Expl. Immunol. 109, 538-546.
Andre, F., Marraud, M., Tsouloufis, T., Tzartos, S.J., Boussard, G. (1997) Triphosgene: An efficient carbonylating agent for liquid and solid-phase aza-peptide synthesis. Application to the synthesis of two aza-analogues of the AChR MIR decapeptide. J. Pep. Science . 3: 429-441
Voltz, R., Kamm, C., Padberg, F., Malotka, J., Kerschensteiner, M., Spuler, S., Tzartos, S., and Dornmair, K. (1997) Highly purified oligo-His tagged human recombinant alpha(1)-AChR is immunogenic in vivo and suitable for T cell stimulation in vitro in experimental and human myasthenia gravis. J.Neuroimmunol. 80:131-136.
Bufler, J., Kahlert, S., Tzartos, S.J., Toyka, C. and Franke, C. (1996). Activation and blockage of nicotinic channels by antibodies directed against the binding site of the acetylcholine receptor. J. Physiol. 492: 107-114
Kontou, M., Vatzaki, E.H., Kokla, A., Acharya, K.R., Oikonomakos, N.G. and Tzartos, S.J. (1996). Characterisation, crystallisation and preliminary X-ray diffraction analysis of a Fab fragment of a rat monoclonal antibody with very high affinity for the human muscle acetylcholine receptor. FEBS Lett. 389: 195-198.
Wakkach, A., Guyon, T., Bruand, C., Tzartos, S., Cohen-Kaminsky, S. and Berrih-Aknin, S. (1996) Expression of acetylcholine receptor genes in human thymic epithelial cells. Implication for myasthenia gravis. J. Immunol. 157: 3752-3760.
Pappas, I.S., Sophianos, D., Tzartos, S.J. and Tsiftsoglou, A.S. (1996). Expression of memory, differentiation and repression of c-myc and p53 genes in human RD/TE-671 cells induced by a uveido-derivative of pyridine (UDP-4). Cell Growth and Differentiation. 7: 797-809.
Tsikaris, V., Sakarellos, C., Sakarellos-Daitsiotis, M., Orlewski, P., Marraud, M. Cung, M.T., Vatzaki, E., and Tzartos, S.J. (1996). Construction and application of a new class of sequential oligopeptide carriers for multiple anchoring of antigenic peptides. Application to the AChR main immunogenic region. Intern. J. Biol. Macromol. 19: 195-205.
Tzartos, S.J., Kouvatsou, R. and Tzartos E. (1995) Monoclonal antibodies as site-specific probes for the acetylcholine receptor δ-subunit tyrosine and serine phosphorylation sites. Eur. J. Biochem. 228, 463-472.
Mapouras, D., Philippou, G., Charalabous, S., Tzartos, S.J. Balafas, A., Souvatzoglou, A. and Lymberi, P. (1995). Antibodies to acetylcholinesterase cross-reacting with thyroglobulin in myasthenia gravis and graves disease. Clin. Exp. Immunol 100: 336-343.
Tzartos, S.J., Tzartos, E., and Tzartos, J.S. (1995) Monoclonal antibodies against the acetylcholine receptor γ-subunit as site specific probes for receptor tyrosine phosphorylation. FEBS Letters. 363: 195-198.
Mamalaki, A., Boutou, E., Hurel, C., Patsavoudi, E., Tzartos, S.J. and Matsas, R. (1995). The BM88 antigen, a novel neuron-specific molecule, promotes the differentiation of mouse neuroblastoma cells. J. Biol. Chem. 270: 14201-14208.
Asher, O., Kues, W.A., Witzemann, V.,Tzartos, S.J., Fuchs, S. and Souroujon, M.C. (1993) Increased gene expression of acetylcholine receptor and myogenic factors in passively transferred experimental autoimmune myasthenia gravis. J. Immunol. 151, 6442-6450.
Schmutz, M., Kling, D., Tzartos, S.J. and Brisson, A. (1994). A mixed ELISA-immunoelectron microscopy approach for studying epitope topology of membrane proteins: application to the acetylcholine receptor. J. Histochem. Cytochem. 42, 315-327 (1994).
Tzartos, S.J., Valcana, C., Kouvatsou, R., and Kokla, A. (1993) The tyrosine phosphorylation site of the acetylcholine receptor β-subunit is located in a highly immunogenic epitope implicated in channel function. Antibody-probes for β subunit phosphorylation and function. EMBO J. 12, 5141-5149.
Papadouli, I., Sakarellos, C.,and Tzartos, S.T. (1993). High resolution epitope mapping and fine antigenic characterization of the main immunogenic region of the acetylcholine receptor. Improving the binding activity of synthetic analogues of the region. Eur. J. Biochem. 211, 227-234.
Eleftheriou, C.S., Trakas, N., Kokla, A. and Tzartos, S.J. (1993). A group of three fibroblast secreted polypeptides suppressed by cellular ageing and interferon-γ. Bioch. Bioph. Acta. 1180, 304-312.
Detsikas, E., Tsikaris, V., Sakarellos-Daitsiotis, M., Sakarellos, C., Cung, M.T., Marraud, M., Vatzaki, E. and Tzartos, S.J. (1993). Cyclic lactam analogues containing the main immunogenic region of Torpedo acetylcholine receptor. Peptide Research 6, 17-23.
Tsikaris, V., Detsikas, E., Sakarellos-Daitsiotis, M., Sakarellos, C., Vatzaki, E., Tzartos, S.J., Marraud, M. and Cung, M.T., (1993). Conformational requirements for molecular recognition of ACh receptor MIR analogues by monoclonal anti-MIR antibody: A 2D-NMR and molecular dynamics approach. Biopolymers. 33, 1123-1134.
Mamalaki, A., Trakas, N., and Tzartos, S.J. (1993). Bacterial expression of a single-chain Fv fragment which efficiently protects the acetylcholine receptor against antigenic modulation caused by myasthenic antibodies. Eur. J. Immunol. 23, 1839-1845.
Melms, A., Weissert, R., Klinkert, W.E.F., Schalke, B.C.G., Tzartos, S. and Wekerle, H. (1993). Specific immune complexes augment in vitro acetylcholine receptor-specific T-cell proliferation. Neurology 43, 583-588.
Vatzaki, E. H., Acharya, K.R., Oikonomakos, N. G. and Tzartos, S.J. (1993). Crystallization and preliminary crystallographic study of an Fab fragment of a pathogenic rat monoclonal antibody against the nicotinic acetylcholine receptor. Protein Science. 2: 1770-1772.
Loutrari, H., Tzartos, S.J. and Claudio, T. (1992). Use of Torpedo-mouse hybrid acetylcholine receptors reveals immunodominance of the α-subunit in myasthenia gravis antisera. Eur. J. Immunol. 22, 2949-2956.
Loutrari, H., Kokla, A. and Tzartos, S.J. (1992). Passive transfer of experimental myasthenia gravis via antigenic modulation of acetylcholine receptor. Eur. J. Immunol. 22, 2449-2452.
Zhang, Y., and Tzartos, S.J. (1992). B-T lymphocyte interactions in experimental autoimmune myasthenia gravis. Autoantibody mediated up-regulation of the response of AChR-specific T-lymphocytes. Immunology 77, 571-576.
Marx, A., Osborn, M., Tzartos, S., Geuder, K.I., Schalke, B., Nix, W., Kirchner, T., and Muller-Hermelink, H.K. (1992). A striational muscle antigen and myasthenia gravis-associated thymomas share an acetylcholine receptor epitope. Develop. Immunol. 2, 77-84.
Cung, M.T., Demange, P., Marraud, M., Tsikaris, V., Sakarellos, C., Papadouli, I., Kokla, A., Tzartos, S.J. (1991). Two-dimentional 1H-NMR study of antigen-antibody interactions: binding of synthetic decapeptides to an anti-acetylcholine receptor monoclonal antibody. Biopolymers. 31, 769-776.
Verschuuren, J.J.G.M., Graus Y.M.F., Bos N.A., Tzartos S.J., Van Breda Vriesman P.J.C., and De Baets M.H. (1991). Paratope and framework related idiotopes on acetylcholine receptor antibodies. J. Immunol. 146, 941-948.
Verschuuren, J.J.G.M., Graus Y.M.F., Van Breda Vriesman P.J.C., Tzartos S.J., and De Baets M.H. (1991). In vivo effects of neonatal administration of anti-idiotype antibodies on experimental autoimmune myasthenia gravis Autoimmunity. 10:173-179.
Tzartos, S. J., Loutrari, H., Tang, F., Kokla, A., Walgrave, S., Milius, R. P. and Conti-Tronconi, B. (1990). Main immunogenic region of Torpedo electroplax and human muscle acetylcholine receptor. Localization and micro-heterogeneity reveiled by the use of synthetic peptides. J. Neurochem. 54, 51-61.
Plinkert, P.K., Gitter, A.H., Zimmermann, U., Kirchner, T., Tzartos, S. and Zenner, H.P. (1990). Visualization and functional testing of acetylcholine receptor-like molecules in cochlear outer hair cells. Hearing Res. 44, 25-34.
Marx, A., O' Connor, R., Geuder, K.I., Hoppe, F., Schalke, B., Tzartos, S., Kalies, I., Kirchner, T., and Muller-Hermelink, H. K. (1990). Characterization of a protein with an acetylcholine receptor epitope from myasthenia gravis-associated thymomas. Lab. Invest.. 62, 279-286.
Tzartos, S.J., Efthimiadis, A., Morel, E. and Bach, J.F. (1990) Neonatal myasthenia gravis: antigenic specificities of antibodies in sera from mothers and their infants. Clin. Exp. Immunol. 80, 376-380.
Papadouli, I., Potamianos, S., Hadjidakis, I., Bairaktari, H., Tsikaris, V., Sakarellos, C., Cung, M.T., Marraud, M. and Tzartos, S.J. (1990). Antigenic role of single residues within the main immunogenic region of the nicotinic acetylcholine receptor. Biochem. J. 269, 239-245.
Tzartos, S.J and Remoundos, M.S. (1990). Fine localization of the major α-bungarotoxin binding site to residues α189-195 of the Torpedo acetylcholine receptor. Residues 189, 190 and 195 are indispensable for binding. J. Biol. Chem. 265, 21462-21467.
| | Reviews |
2000-2008
Tzartos, S.J., Bitzopoulou, K., Gavra, I., Kordas, G., Jacobson, L., Kostelidou, K., Lagoumintzis, G., Lazos, O., Poulas, K., Sideris, S., Sotiriadis, A., Trakas, N.,and
Zisimopoulou, P. (2008) Antigen-specific apheresis of pathogenic autoantibodies from myasthenia gravis sera. Ann. N.Y Acad. Sci., 1132:291-9.
Kostelidou, K., Sideri, A., Lazaridis, K., Fostieri, E., and Tzartos, S. (2008). Emerging therapies for the treatment of autoimmune myasthenia gravis. Βόκ: Clinical Applications of Immunomics, Immunomics Series. Ed. Andras Falus. Springer. pp. 171-205.
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