Researchers from the Laboratory of Cellular and Molecular Neurobiology – Stem Cells and the Human Stem Cell Unit published a review article in Frontiers in Cellular Νeuroscience discussing the pivotal role of small non-coding miRNAs in shaping human brain development and disease. The use of human pluripotent stem cells and brain organoids, permitting experimental access to neural cells and differentiation stages that are otherwise difficult or impossible to reach in humans, is critical for identification of the unique features of human brain evolution.
Species-Specific miRNAs in Human Brain Development and Disease
Kanella Prodromidou and Rebecca Matsas
Front Cell Neurosci 13, 559 eCollection 2019 DOI: 10.3389/fncel.2019.00559