Pasteur

The following services are offered:

• Breeding, distribution and use of classic and transgenic strains of mice and rats, guinea pigs
• Maintenance of rabbits
• Housing of laboratory animals  
• Handling of immunodeficient mice
• Veterinary care
• Substances administration (intravenous (i.v.), intraperitoneal (i.p.), intramuscular(i.m.), subcutaneous(s.c.), per os,
• Blood, serum, plasma, tissues collection
• Anesthesia and analgesia
• Preclinical studies in animal models
• Toxicological studies
• Generation of complex transgenic mouse strains and maintenance of their colonies
• Consultancy

in collaboration with Transgenic Technology Laboratory are performed :

• Embryo Transfers and Rederivation
• Cryopreservation of embryos and sperm and biobanking of germ cells
• Vasectomized males and pseudopregnant recipient females for transgenesis protocols
• DAMBR collaborates with other research groups and infrastructures and with Diagnosis and Vaccines Quality Control Department of HPI.

In the Facilities, HPI researchers run experimental protocols using laboratory animals for modeling human diseases. They possess highly specialized know-how related to infectious diseases, cancer induction, autoimmune experimental encephalomyelitis, rheumatoid arthritis, inflammatory bowel disease,  atherosclerosis, ischemia, temporary (tMCAO) or permanent (pMCAO) occlusion of the middle cerebral artery or carotid, brain and spinal cord trauma, ex vivo transplantation, agents administration by stereotactic injection into the brain and spinal cord, behavioral studies,  tissue collection for the preparation of frozen and paraffin-embedded tissues.

Each specialized work is carried out under the core responsibility of scientific research laboratories of HPI.

Annual Institutional training courses

2016

«Introduction to Laboratory Animals Science», 25-26 May.

2014

«Laboratory Animals: change of paradigm», 30 May.

2013

«Laboratory Animals as tools of translational research»,  26 April.

2012

«Laboratory Animals and daily research practices», 14 December.

International training courses

2017

Participation ΤΤ-RIIP «TRANSGENIC TECHNOLOGIES in  MODELING HUMAN DISEASES: Principles, Associated Technologies, Animal Management and Ethics »,  5-13 June.

2015

Organization LAS _RIIP «Laboratory Animals in Biomedical Research: Τheory and Practice»,  8-25 May 2015.

Personnel professional development and training by participating in international training course

2017

The implementation of the 3R’s in the experimental design, Guido Bernadini, Fondatione (FGB), 23-24 November.

2016

2nd LAS-EU functions course, University of Athens, KAT Hospital, 12-21 September, Athens.

FELASA to train Designated Veterinarians (FELASA Category D), LabVet, University of Copenhagen.

2015

Introduction to Laboratory Animal Science (FELASA cat. C accredited), EMBL, 13-24 April, Monterotondo.

1st LAS-EU functions course, University of Athens, KAT Hospital, 9-17 November, Athens.

2014

Workshop on Surgical Techniques in the Laboratory Mouse, Universite Pierre et Marie Curie (UPMC), The Jackson Laboratory, 24-27 June, Paris.

Course on Cryopreservation of mouse germplasm, 20 – 24 October  Monterotondo, Italy.

The implementation of EU Education and Training Framework under Directive 2010/63/EU, Fondazione Guido Bernadini, 30–31 October, Varese, Italy

2013

Laboratory Animal Necropsy and Sample Collection”, 5-hours practical course, Biomedical Research Foundation of the Academy of Athens, Division of Laboratory  Animal Facilities, 12 November.

“The emerging field of microbiota and the effects on animal models”, Fondazione Guido Bernadini, Buguggiate, 21-22 November

2012

«Handling and techniques of small animal models», Institute of Experimental

 Surgery Center of Biomedical Research of the Academy of Athens, 12–14 December

Introductory Course in Animal Science (FELASA cat. B accredited). University of Zürich, 27-31 August.