Research in the Department of Immunology focuses upon understanding how the immune system functions to maintain homeostasis under physiological conditions and after infection or injury, and how immune system dysfunction contributes to the development of human disease. A range of human pathologies are studied, mainly chronic immune diseases such as multiple sclerosis, autoimmune thyroiditis, rheumatoid arthritis and Sjogren’s syndrome, iron homeostasis diseases and cancer. Major aims are to develop immune therapies and biomarkers for these conditions. The research approach involves study of human cells, tissues and fluids, of natural cell-penetrating antibodies, development of human monoclonal antibodies for immunotherapy, and use of a rich array of experimental models in combination with immune-targeted and humanized mice. The Department of Immunology is supported by five research groups led by 5 principal investigators. It is actively involved in training undergraduate and graduate students from national and international Universities.