Publication in the high impact journal Nature Communications

Researchers of the Laboratory of Cellular & Molecular Neurobiology – Stem Cells in collaboration with the Laboratory of Bacteriology and the Institut Pasteur in Paris (Group of Brain Plasticity in Response to the Environment and the Unité de Biologie des Bactéries Pathogènes à Gram-positif) discovered that Streptococcus Group B which causes neonatal encephalitis, crosses the blood-brain barrier and invades the brain via binding of the bacterial lipoprotein Blr with the host endothelial cell receptor LpR2.

Billel Benmimoun, Florentia Papastefanaki, Bruno Périchon, Katerina Segklia, Nicolas Roby, Vivi Miriagou, Christine Schmitt, Shaynoor Dramsi, Rebecca Matsas & Pauline Spéder.  An original infection model identifies host lipoprotein import as a route for blood-brain barrier crossing. Nat Commun 11, 6106 (2020).