The human cerebral cortex is one of the most complex structures in the brain responsible for high-order cognitive functions and social behavior as well as sensory, motor and emotional control, while its impairment results in neurodevelopmental, neuropsychiatric and neurodegenerative disorders. It encompasses an unparalleled diversity of neuronal types and subtypes that arise during development through a series of evolutionary conserved processes, and human-associated adaptations. Disentangling the unique features of human cortical development involves elucidation of the intricate developmental cell processes orchestrated by progressive molecular events. Recent advances in bulk and single-cell transcriptomic technologies suggest that alongside protein-coding genes, non-coding RNAs exert important regulatory roles in these processes.
Evolving features of human cortical development and the emerging roles of non-coding RNAs in neural progenitor cell diversity and function
Kanella Prodromidou and Rebecca Matsas
Cell Mol Life Sci. 2021 Dec 18;79(1):56. https://doi.org/10.1007/s00018-021-04063-7