Systemic NLRP3 inflammasome activation in severe Sjögren’s syndrome, associates with widespread extranuclear accumulations of inflammagenic DNA and impaired DNA degradation

Findings that can provide novel biomarkers and new therapeutic targets for the management of SS patients with adverse outcomes.

J Autoimmun. 91:23-33 Epub 2018 Mar 16

Publication in high Impact factor peer reviewed journal (IF:7.607)

Authors : Vakrakou AG1, Boiu S1, Ziakas PD2, Xingi E3, Boleti H3, Manoussakis MN4

COLLABORATION between

1 Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece; Laboratory of Molecular Immunology, Hellenic Pasteur Institute, Athens, Greece. 
2 Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
3 Light Microscopy Unit, Hellenic Pasteur Institute, Athens, Greece.
4 Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece; Laboratory of Molecular Immunology, Hellenic Pasteur Institute, Athens, Greece; Joint Academic Rheumatology Program, National and Kapodistrian University of Athens, Athens, Greece.

Coresponding author: Manoussakis MN  .img@.img">.img@.img